| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 1 [1-535] |
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| Ligand | BDBM598584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
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| IC50 | 0.200±n/a nM |
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| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rho-associated protein kinase 1 [1-535] |
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| Name: | Rho-associated protein kinase 1 [1-535] |
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| Synonyms: | ROCK1 | ROCK1_HUMAN | Rho-associated protein kinase 1 (ROCK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 62220.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-535 |
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| Residue: | 535 |
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| Sequence: | MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQL
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| BDBM598584 |
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| n/a |
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| Name | BDBM598584 |
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| Synonyms: | N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methylpyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 213 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N7 |
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| Mol. Mass. | 321.3797 |
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| SMILES | Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CC1CNC2 |
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| Structure | 
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