| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [1-552] |
|---|
| Ligand | BDBM598636 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
|---|
| IC50 | 2.60±n/a nM |
|---|
| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Rho-associated protein kinase 2 [1-552] |
|---|
| Name: | Rho-associated protein kinase 2 [1-552] |
|---|
| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 63353.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | aa 1-552 |
|---|
| Residue: | 552 |
|---|
| Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQI
|
|
|
|---|
| BDBM598636 |
|---|
| n/a |
|---|
| Name | BDBM598636 |
|---|
| Synonyms: | 2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-N-(1H-indazol-5-yl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-amine | US11613531, Example 307 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H21N7O |
|---|
| Mol. Mass. | 363.4163 |
|---|
| SMILES | C1C2CNCC1N2c1nc2CCOCc2c(Nc2ccc3[nH]ncc3c2)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
