| Reaction Details |
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 | Report a problem with these data |
| Target | Rho-associated protein kinase 2 [1-552] |
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| Ligand | BDBM598647 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Determination of Compound's ROCK Inhibitory Activity In Vitro (Z'Lyte Assay) |
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| IC50 | 1.10±n/a nM |
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| Citation |  Skucas, E; Liu, KG; Kim, J; Poyurovsky, MV; Mo, R Inhibitors of RHO associated coiled-coil containing protein kinase US Patent US11613531 Publication Date 3/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Rho-associated protein kinase 2 [1-552] |
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| Name: | Rho-associated protein kinase 2 [1-552] |
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| Synonyms: | KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho-associated protein kinase 2 (ROCK2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 63353.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 1-552 |
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| Residue: | 552 |
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| Sequence: | MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFP
ALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAM
KLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNL
MSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMD
ETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLV
GTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH
WDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENL
LLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKT
AKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQL
EDLKKRNQNSQI
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| BDBM598647 |
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| n/a |
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| Name | BDBM598647 |
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| Synonyms: | N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-fluoro-6-methoxypyrimidin-4-yl)-1H-indazol-5-amine | US11613531, Example 319 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20FN7O |
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| Mol. Mass. | 369.3961 |
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| SMILES | COc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2 |
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| Structure | 
|
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