| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha |
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| Ligand | BDBM50399656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Identification of CSNK1A1 Inhibitors |
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| IC50 | 857±n/a nM |
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| Citation |  Corsello, SM; Golub, TR; Stefan, E; Hilgraf, R Compounds and methods useful for treating or preventing cancers US Patent US11633415 Publication Date 4/25/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha |
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| Name: | Casein kinase I isoform alpha |
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| Synonyms: | CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 38936.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48729 |
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| Residue: | 337 |
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| Sequence: | MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
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| BDBM50399656 |
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| n/a |
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| Name | BDBM50399656 |
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| Synonyms: | CHEMBL2069623 | US11633415, Compound PF4800567 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18ClN5O2 |
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| Mol. Mass. | 359.81 |
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| SMILES | Nc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1 |
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| Structure | 
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