| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM310722 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC inhibitory assay |
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| IC50 | >10000±n/a nM |
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| Citation |  Shuttleworth, SJ; Tomassi, CD; Cecil, AR; MacCormick, S; Nodes, WJ; Silva, FA Histone deacetylase inhibitors and their use in therapy US Patent US10150763 Publication Date 12/11/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM310722 |
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| n/a |
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| Name | BDBM310722 |
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| Synonyms: | 8-((5-Fluoropyridin-2-yl)(1-methyl-1H-pyrazol-3-yl)amino)-N-hydroxyoctanamide | US10150763, Example V |
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| Type | Small organic molecule |
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| Emp. Form. | C17H24FN5O2 |
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| Mol. Mass. | 349.4032 |
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| SMILES | Cn1ccc(n1)N(CCCCCCCC(=O)NO)c1ccc(F)cn1 |
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| Structure | 
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