| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM601998 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pim-1 Inhibitory Activity Assay |
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| Ki | 0.058±n/a nM |
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| Citation |  Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent US11643417 Publication Date 5/9/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM601998 |
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| n/a |
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| Name | BDBM601998 |
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| Synonyms: | US11643417, Ex. No. 30 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25F5N2O5 |
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| Mol. Mass. | 492.4363 |
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| SMILES | CC(C)(O)C1(O)CCOC(C1)C(F)(F)CN1CCNC(=O)c2oc3ccc(cc3c12)C(F)(F)F |
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| Structure | 
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