Reaction Details | |||
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Target | Serine/threonine-protein kinase pim-1 | ||
Ligand | BDBM602112 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Pim-1 Inhibitory Activity Assay | ||
Ki | 0.059±n/a nM | ||
Citation | Inoue, M; Ogoshi, Y; Furukawa, T; Machida, T; Mitani, I; Harada, K; Nakagawa, Y; Yamaoka, N Tetrahydrobenzofurodiazepinone compound and pharmaceutical use thereof US Patent US11643417 Publication Date 5/9/2023 | ||
More Info.: | Get all data from this article, Assay Method | ||
Serine/threonine-protein kinase pim-1 | |||
Name: | Serine/threonine-protein kinase pim-1 | ||
Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | ||
Type: | Protein | ||
Mol. Mass.: | 35681.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11309 | ||
Residue: | 313 | ||
Sequence: |
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BDBM602112 | |||
n/a | |||
Name | BDBM602112 | ||
Synonyms: | US11643417, Ex. No. 125 | US11643417, Ex. No. 126 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H25F3N2O3 | ||
Mol. Mass. | 422.4407 | ||
SMILES | OC1CCC(CCN2CC3(CC3)NC(=O)c3oc4ccc(cc4c23)C(F)(F)F)CC1 |(6.71,.26,;5.25,.76,;4.09,-.25,;2.63,.25,;2.34,1.76,;.88,2.25,;-.28,1.24,;-1.74,1.74,;-1.92,3.27,;-3.23,4.08,;-2.61,5.48,;-4.14,5.32,;-4.68,3.56,;-5.18,2.1,;-6.71,1.92,;-4.35,.8,;-4.98,-.6,;-3.83,-1.63,;-3.83,-3.17,;-2.5,-3.94,;-1.16,-3.17,;-1.16,-1.63,;-2.5,-.86,;-2.82,.64,;.17,-3.94,;1.5,-3.17,;.17,-5.48,;.17,-2.4,;3.5,2.77,;4.95,2.27,)| | ||
Structure |