Reaction Details |
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Target | Son of sevenless homolog 1 |
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Ligand | BDBM602201 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Ras-SOS Interaction Assay |
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IC50 | <100±n/a nM |
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Citation | Wu, B; Wang, X; Li, X; Chen, Z; Ren, P; Liu, Y Substituted pyrido[2,3-d]pyrimidines as inhibitors of Ras pathway signaling US Patent US11648254 Publication Date 5/16/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Son of sevenless homolog 1 |
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Name: | Son of sevenless homolog 1 |
Synonyms: | SOS-1 | SOS1 | SOS1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 152470.33 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_839705 |
Residue: | 1333 |
Sequence: | MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV
ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKI
LEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK
RRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRN
PKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAP
NSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISL
TKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISD
RTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPP
PQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMH
RDGPPLLENAHSS
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BDBM602201 |
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n/a |
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Name | BDBM602201 |
Synonyms: | (R)-N-(1-(3-(difluoromethyl)-2- fluorophenyl)ethyl)-6-(1- isopropylpiperidin-4-yl)-7-methoxy-2- methylpyrido[2,3-d]pyrimidin-4-amine | US11648254, Compound 112 |
Type | Small organic molecule |
Emp. Form. | C26H32F3N5O |
Mol. Mass. | 487.5604 |
SMILES | COc1nc2nc(C)nc(N[C@H](C)c3cccc(C(F)F)c3F)c2cc1C1CCN(CC1)C(C)C |r| |
Structure |
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