| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 [1-321] |
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| Ligand | BDBM50233538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Metabolic Measurements |
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| Ki | 10000±n/a nM |
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| Citation |  Tonks, N; Krishnan, N Treatment of Rett syndrome US Patent US11660306 Publication Date 5/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 [1-321] |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 [1-321] |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 37311.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P18031 (1-321 aa) |
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| Residue: | 321 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHN
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| BDBM50233538 |
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| n/a |
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| Name | BDBM50233538 |
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| Synonyms: | 18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoolean-12-en-30-oic acid | CHEMBL230006 | US11660306, Example 18beta Glycyrrhetinic acid | glycyrrhetinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C30H46O4 |
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| Mol. Mass. | 470.6838 |
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| SMILES | CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |r,t:19| |
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| Structure | 
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