| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT8 |
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| Ligand | BDBM606538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | KAT-8 Enzyme Assay |
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| IC50 | 30000±n/a nM |
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| Citation |  Harvey, DM; Campbell, JE; Duncan, KW MYST family histone acetyltransferase inhibitors US Patent US11685732 Publication Date 6/27/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT8 |
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| Name: | Histone acetyltransferase KAT8 |
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| Synonyms: | KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52413.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_796800 |
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| Residue: | 458 |
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| Sequence: | MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGET
YLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQ
KNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVD
KIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEI
YRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVG
YFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLS
YRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPK
LVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
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| BDBM606538 |
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| n/a |
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| Name | BDBM606538 |
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| Synonyms: | US11685732, Compound I-182 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19ClFN4O4S |
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| Mol. Mass. | 429.874 |
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| SMILES | Cc1cc(nn1)-c1cc(Cl)c(F)c(c1)C(=O)NNS(=O)(=O)CC1CCOCC1 |
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| Structure | 
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