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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone acetyltransferase KAT8 | ||
| Ligand | BDBM606542 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | KAT-8 Enzyme Assay | ||
| IC50 | 30000±n/a nM | ||
| Citation |  Harvey, DM; Campbell, JE; Duncan, KW MYST family histone acetyltransferase inhibitors US Patent US11685732 Publication Date 6/27/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone acetyltransferase KAT8 | |||
| Name: | Histone acetyltransferase KAT8 | ||
| Synonyms: | KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 52413.66 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_796800 | ||
| Residue: | 458 | ||
| Sequence: |
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| BDBM606542 | |||
| n/a | |||
| Name | BDBM606542 | ||
| Synonyms: | US11685732, Compound I-186 | US11685732, Compound I-197 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22ClFN6O4S | ||
| Mol. Mass. | 472.921 | ||
| SMILES | CNC(=O)N[C@@H]1C[C@H](CS(=O)(=O)NNC(=O)c2cc(cc(Cl)c2F)-c2cn(C)cn2)C1 |r,wU:7.7,5.4,(11.6,-1.7,;10.26,-2.47,;8.93,-1.7,;8.93,-.16,;7.6,-2.47,;6.26,-1.7,;5.86,-.22,;4.38,-.61,;3.04,.16,;1.71,-.61,;.94,.72,;2.48,-1.95,;.37,-1.38,;-.96,-.61,;-2.29,-1.38,;-2.29,-2.92,;-3.63,-.61,;-4.96,-1.38,;-6.29,-.61,;-6.29,.93,;-4.96,1.7,;-4.96,3.24,;-3.63,.93,;-2.29,1.7,;-7.63,-1.38,;-9.03,-.76,;-10.06,-1.9,;-11.6,-1.74,;-9.29,-3.24,;-7.79,-2.92,;4.77,-2.1,)| | ||
| Structure | 
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