Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM607543 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ADP-Glo Kinase Assay |
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IC50 | 20.0±n/a nM |
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Citation | Lewis, RT; Hamilton, M; Ray, WJ; Alvarez, F; Reyna, N; Cross, J; Ramaswamy, SK Inhibitors of receptor interacting protein kinase I for the treatment of disease US Patent US11690850 Publication Date 7/4/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 1 |
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Name: | Receptor-interacting serine/threonine-protein kinase 1 |
Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 75926.99 |
Organism: | Homo sapiens (Human) |
Description: | Q13546 |
Residue: | 671 |
Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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BDBM607543 |
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n/a |
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Name | BDBM607543 |
Synonyms: | US11690850, Example 57 |
Type | Small organic molecule |
Emp. Form. | C22H19FN4O3 |
Mol. Mass. | 406.4097 |
SMILES | Cc1cc(=O)c(nn1-c1ccc(F)cc1)C(=O)NC1CCc2ccccc2NC1=O |
Structure |
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