Reaction Details |
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Target | Transmembrane prolyl 4-hydroxylase |
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Ligand | BDBM511481 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro Kinase Activity Assay |
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IC50 | 4.50±n/a nM |
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Citation | deLong, MA; Carlson, E; Kopczynski, C; Sturdivant, JM; Lichorowic, C Isoquinoline-steroid conjugates and uses thereof US Patent US11691950 Publication Date 7/4/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Transmembrane prolyl 4-hydroxylase |
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Name: | Transmembrane prolyl 4-hydroxylase |
Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 56654.25 |
Organism: | Homo sapiens (Human) |
Description: | Q9NXG6 |
Residue: | 502 |
Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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BDBM511481 |
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n/a |
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Name | BDBM511481 |
Synonyms: | US11059789, Example 25 | US11691950, Example 25 |
Type | Small organic molecule |
Emp. Form. | C45H50FN3O9 |
Mol. Mass. | 795.8916 |
SMILES | C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:11,t:7| |
Structure |
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