| Reaction Details |
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 | Report a problem with these data |
| Target | Transmembrane prolyl 4-hydroxylase |
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| Ligand | BDBM511484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Kinase Activity Assay |
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| IC50 | 4.00±n/a nM |
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| Citation |  deLong, MA; Carlson, E; Kopczynski, C; Sturdivant, JM; Lichorowic, C Isoquinoline-steroid conjugates and uses thereof US Patent US11691950 Publication Date 7/4/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transmembrane prolyl 4-hydroxylase |
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| Name: | Transmembrane prolyl 4-hydroxylase |
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| Synonyms: | Hypoxia-inducible factor prolyl 4-hydroxylase | Hypoxia-inducible factor prolyl hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | Hypoxia-inducible factor prolyl hydroxylase 4 (HIF) | P4HTM | P4HTM_HUMAN | PH4 | Transmembrane prolyl 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56654.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NXG6 |
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| Residue: | 502 |
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| Sequence: | MAAAAVTGQRPETAAAEEASRPQWAPPDHCQAQAAAGLGDGEDAPVRPLCKPRGICSRAY
FLVLMVFVHLYLGNVLALLLFVHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVG
HERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYE
EAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDG
DGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRL
TRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYM
TVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVF
WYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLARE
GGTDSQPEWALDRAYRDARVEL
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| BDBM511484 |
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| n/a |
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| Name | BDBM511484 |
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| Synonyms: | US11059789, Example 33 | US11691950, Example 33 |
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| Type | Small organic molecule |
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| Emp. Form. | C47H52FN3O10 |
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| Mol. Mass. | 837.9283 |
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| SMILES | CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)COC(=O)CCC(=O)OCc1ccc(cc1)[C@@H](CN)C(=O)Nc1ccc2cnccc2c1 |r,c:14,t:10| |
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| Structure | 
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