| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 alpha |
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| Ligand | BDBM610475 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase assay |
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| IC50 | 0.600±n/a nM |
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| Citation |  Hartz, RA; Ahuja, VT; Sivaprakasam, P; Dubowchik, GM; Macor, JE GSK-3 inhibitors US Patent US10774086 Publication Date 9/15/2020 |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 alpha |
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| Name: | Glycogen synthase kinase-3 alpha |
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| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50991.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49840 |
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| Residue: | 483 |
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| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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| BDBM610475 |
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| n/a |
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| Name | BDBM610475 |
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| Synonyms: | N-(4-(4,4-Difluoropiperidin-1-yl)pyridin-3-yl)-2-(2-methoxyphenyl)imidazo[1,2-b]pyridazine-8-carboxamide | US10774086, Example 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22F2N6O2 |
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| Mol. Mass. | 464.4673 |
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| SMILES | COc1ccccc1-c1cn2nccc(C(=O)Nc3cnccc3N3CCC(F)(F)CC3)c2n1 |
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| Structure | 
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