| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Ligand | BDBM611366 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Measurement of TRPA1 Antagonist Activity |
|---|
| IC50 | 1.20±n/a nM |
|---|
| Citation |  Kobayashi, K; Suzuki, T; Fujii, T; Okuzumi, T Heterocyclic sulfonamide derivative and medicine comprising same US Patent US10626112 Publication Date 4/21/2020 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transient receptor potential cation channel subfamily A member 1 |
|---|
| Name: | Transient receptor potential cation channel subfamily A member 1 |
|---|
| Synonyms: | ANKTM1 | Ankyrin-like with transmembrane domains protein 1 | TRPA1 | TRPA1_HUMAN | Transformation-sensitive protein p120 | Transient receptor potential cation channel subfamily A member 1 (TRPA1) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 127514.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75762 |
|---|
| Residue: | 1119 |
|---|
| Sequence: | MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCD
DMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSR
GANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEA
LQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKA
TPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVD
IVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNL
LLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYA
CRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDL
HGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKC
TDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTII
RSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNF
KYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHM
MNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLS
SIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVY
FYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSS
PLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLA
VGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIF
CFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETED
DDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
|
|
|
|---|
| BDBM611366 |
|---|
| n/a |
|---|
| Name | BDBM611366 |
|---|
| Synonyms: | (1S,3S,5S)-4-(5- fluorobenzofuran-2-yl)sulfonyl- N-[[4-[5-(trifluoromethyl)-2- pyridyl]-2-pyridyl]methyl]-4- azabicyclo[3.1.0]hexane-3- carboxamide | US10626112, Example 259 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H20F4N4O4S |
|---|
| Mol. Mass. | 560.52 |
|---|
| SMILES | Fc1ccc2oc(cc2c1)S(=O)(=O)N1[C@H]2C[C@H]2C[C@H]1C(=O)NCc1cc(ccn1)-c1ccc(cn1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
