Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM549197 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biochemical Assay | ||
Ki | <0.1±n/a nM | ||
Citation | Fatheree, PR; Jacobsen, JR; Beausoleil, A; Brandt, GE; Fleury, M; Jiang, L; Smith, C; Sullivan, SD; Van Orden, LJ; Colson, P; Fass, GT; Rapta, M; Benjamin, N; Dabros, M; Thalladi, VR JAK kinase inhibitor compounds for treatment of respiratory disease US Patent US11718616 Publication Date 8/8/2023 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM549197 | |||
n/a | |||
Name | BDBM549197 | ||
Synonyms: | US11299492, Example 3-30 | US11718616, Example 3-30 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H33FN6O2 | ||
Mol. Mass. | 504.599 | ||
SMILES | CCc1cc(O)c(F)cc1-c1ccc2c(n[nH]c2c1)-c1nc2CN(CCNC3CC(C3)OC)CCc2[nH]1 |(-9.49,-2.64,;-8.13,-1.85,;-8.11,-.27,;-9.44,.46,;-9.44,2.04,;-10.82,2.74,;-8.13,2.77,;-8.11,4.29,;-6.8,2.01,;-6.8,.49,;-5.44,-.3,;-4.14,.43,;-2.78,-.3,;-2.81,-1.82,;-1.61,-2.85,;-2.27,-4.29,;-3.81,-4.13,;-4.09,-2.58,;-5.44,-1.82,;-.09,-2.55,;.81,-1.31,;2.28,-1.78,;3.61,-1.01,;4.94,-1.78,;6.28,-1.01,;7.61,-1.78,;8.94,-1.01,;10.28,-1.78,;10.52,-3.31,;12.04,-3.06,;11.8,-1.54,;13.29,-3.97,;14.73,-3.33,;4.94,-3.32,;3.61,-4.09,;2.28,-3.32,;.81,-3.8,)| | ||
Structure |