Reaction Details |
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Target | Synaptic vesicular amine transporter |
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Ligand | BDBM611876 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Methods for Determining VMAT2 Inhibitory Activity of a Compound |
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Ki | 1.60±n/a nM |
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Citation | Harriott, N; Pagano, N; Boon, BA Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors US Patent US11718618 Publication Date 8/8/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter |
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Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2 |
Type: | PROTEIN |
Mol. Mass.: | 55709.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_610810 |
Residue: | 514 |
Sequence: | MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
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BDBM611876 |
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n/a |
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Name | BDBM611876 |
Synonyms: | (2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-[(1- fluorocyclopropyl)methoxy]- 10-methoxy- 1H,2H,3H,4H,6H,7H,11bH- pyrido[2,1-a]isoquinolin-2-ol | US11718618, Compound 4-31 |
Type | Small organic molecule |
Emp. Form. | C23H34FNO3 |
Mol. Mass. | 391.5194 |
SMILES | COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)(C)C)CN3CCc2cc1OCC1(F)CC1 |r| |
Structure |
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