Reaction Details |
| Report a problem with these data |
Target | Synaptic vesicular amine transporter |
---|
Ligand | BDBM611890 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Methods for Determining VMAT2 Inhibitory Activity of a Compound |
---|
Ki | 7.30±n/a nM |
---|
Citation | Harriott, N; Pagano, N; Boon, BA Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors US Patent US11718618 Publication Date 8/8/2023 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Synaptic vesicular amine transporter |
---|
Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2 |
Type: | PROTEIN |
Mol. Mass.: | 55709.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_610810 |
Residue: | 514 |
Sequence: | MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
|
|
|
BDBM611890 |
---|
n/a |
---|
Name | BDBM611890 |
Synonyms: | 1-(2-{[(2R,3R,11bR)-3-(2,2- dimethylpropyl)-2-hydroxy- 10-methoxy- 1H,2H,3H,4H,6H,7H,11bH- pyrido[2,1-a]isoquinolin-9- yl]oxy}ethyl)cyclopropane-1- carbonitrile | US11718618, Compound 4-45 |
Type | Small organic molecule |
Emp. Form. | C25H36N2O3 |
Mol. Mass. | 412.5649 |
SMILES | COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)(C)C)CN3CCc2cc1OCCC1(CC1)C#N |r| |
Structure |
|