| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM611910 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Methods for Determining VMAT2 Inhibitory Activity of a Compound |
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| Ki | 3.50±n/a nM |
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| Citation |  Harriott, N; Pagano, N; Boon, BA Substituted pyrido[2,1-a]isoquinolines as VMAT2 inhibitors US Patent US11718618 Publication Date 8/8/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55709.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_610810 |
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| Residue: | 514 |
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| Sequence: | MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
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| BDBM611910 |
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| n/a |
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| Name | BDBM611910 |
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| Synonyms: | (2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-[(1- fluorocyclobutyl)methoxy]-10- methoxy- 1H,2H,3H,4H,6H,7H,11bH- pyrido[2,1-a]isoquinolin-2-ol | US11718618, Compound 4-61 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H36FNO3 |
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| Mol. Mass. | 405.5459 |
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| SMILES | COc1cc2[C@H]3C[C@@H](O)[C@H](CC(C)(C)C)CN3CCc2cc1OCC1(F)CCC1 |r| |
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| Structure | 
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