| Reaction Details |
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 | Report a problem with these data |
| Target | NACHT, LRR and PYD domains-containing protein 3 |
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| Ligand | BDBM612377 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | hTHP-1 assay |
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| IC50 | 24±n/a nM |
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| Citation |  Franchi, L; Ghosh, S; Glick, G; Katz, J; Opipari, Jr., AW; Roush, W; Seidel, HM; Shen, D; Venkatraman, S; Winkler, DG Compounds and compositions for treating conditions associated with NLRP activity US Patent US11724992 Publication Date 8/15/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| NACHT, LRR and PYD domains-containing protein 3 |
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| Name: | NACHT, LRR and PYD domains-containing protein 3 |
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| Synonyms: | C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 118173.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96P20 |
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| Residue: | 1036 |
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| Sequence: | MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
LQEEKPELTVVFEPSW
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| BDBM612377 |
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| n/a |
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| Name | BDBM612377 |
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| Synonyms: | BDBM612516 | BDBM612517 | N'-(1,2,3,5,6,7-hexahydro-s- indacen-4-ylcarbamoyl)-4-(2- hydroxypropan-2-yl)thiophene-2- sulfonimidamide | US11724992, Example 74 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N3O3S2 |
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| Mol. Mass. | 419.561 |
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| SMILES | CC(C)(O)c1csc(c1)S(N)(=O)=NC(=O)Nc1c2CCCc2cc2CCCc12 |
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| Structure | 
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