Reaction Details |
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Target | NACHT, LRR and PYD domains-containing protein 3 |
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Ligand | BDBM612573 |
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Substrate/Competitor | n/a |
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Meas. Tech. | hTHP-1 assay |
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IC50 | 24±n/a nM |
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Citation | Franchi, L; Ghosh, S; Glick, G; Katz, J; Opipari, Jr., AW; Roush, W; Seidel, HM; Shen, D; Venkatraman, S; Winkler, DG Compounds and compositions for treating conditions associated with NLRP activity US Patent US11724992 Publication Date 8/15/2023 |
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More Info.: | Get all data from this article, Assay Method |
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NACHT, LRR and PYD domains-containing protein 3 |
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Name: | NACHT, LRR and PYD domains-containing protein 3 |
Synonyms: | C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 118173.88 |
Organism: | Homo sapiens (Human) |
Description: | Q96P20 |
Residue: | 1036 |
Sequence: | MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
LQEEKPELTVVFEPSW
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BDBM612573 |
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n/a |
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Name | BDBM612573 |
Synonyms: | 4-(2-Hydroxypropan-2-yl)- N'-((2,4,5,6-tetrahydro-1H- cyclobuta[f]inden-3-yl) carbamoyl)thiazole-2- sulfonimidamide | US11724992, Example 262 |
Type | Small organic molecule |
Emp. Form. | C18H22N4O3S2 |
Mol. Mass. | 406.522 |
SMILES | CC(C)(O)c1csc(n1)S(N)(=O)=NC(=O)Nc1c2CCc2cc2CCCc12 |
Structure |
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