Reaction Details |
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Target | NACHT, LRR and PYD domains-containing protein 3 |
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Ligand | BDBM612331 |
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Substrate/Competitor | n/a |
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Meas. Tech. | hTHP-1 assay |
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IC50 | 24±n/a nM |
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Citation | Franchi, L; Ghosh, S; Glick, G; Katz, J; Opipari, Jr., AW; Roush, W; Seidel, HM; Shen, D; Venkatraman, S; Winkler, DG Compounds and compositions for treating conditions associated with NLRP activity US Patent US11724992 Publication Date 8/15/2023 |
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More Info.: | Get all data from this article, Assay Method |
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NACHT, LRR and PYD domains-containing protein 3 |
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Name: | NACHT, LRR and PYD domains-containing protein 3 |
Synonyms: | C1orf7 | CIAS1 | NALP3 | NLRP3 | NLRP3 protein | NLRP3_HUMAN | PYPAF1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 118173.88 |
Organism: | Homo sapiens (Human) |
Description: | Q96P20 |
Residue: | 1036 |
Sequence: | MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
LQEEKPELTVVFEPSW
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BDBM612331 |
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n/a |
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Name | BDBM612331 |
Synonyms: | 4-(2-hydroxypropan-2-yl)-5-methyl- N'-((1-methyl-1,2,3,5,6,7-hexahydro- s-indacen-4-yl)carbamoyl)furan-2- sulfonimidamide | BDBM612435 | BDBM612437 | BDBM612612 | BDBM612613 | US11724992, Example 32 |
Type | Small organic molecule |
Emp. Form. | C22H29N3O4S |
Mol. Mass. | 431.548 |
SMILES | CC1CCc2cc3CCCc3c(NC(=O)N=S(N)(=O)c3cc(c(C)o3)C(C)(C)O)c12 |
Structure |
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