| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase 13 |
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| Ligand | BDBM616232 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Estrone Detection Assay for Evaluation of HSD17I313 Activity |
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| IC50 | <100±n/a nM |
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| Citation |  ANANDAN, SK; ODINGO, J; HSU, HK; FLORIO, V; TANTRY, SJ; DURAISWAMY, AJ DICHLOROPHENOL HSD17B13 INHIBITORS AND USES THEREOF US Patent US20230278981 Publication Date 9/7/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase 13 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase 13 |
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| Synonyms: | 17-beta-HSD 13 | Hepatic retinol/retinal dehydrogenase | Short chain dehydrogenase/reductase family 16C member 3 | Short-chain dehydrogenase/reductase 9 |
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| Type: | Protein |
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| Mol. Mass.: | 33667.14 |
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| Organism: | Human |
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| Description: | Q7Z5P4 |
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| Residue: | 300 |
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| Sequence: | MNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQ
SILVLWDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNN
AGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIP
YLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETD
EVVRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVVGHKIKMK
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| BDBM616232 |
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| n/a |
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| Name | BDBM616232 |
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| Synonyms: | 4,6-dichloro-N-{3-[(1S)-1-(3- fluorophenyl)ethyl]-4-oxo-3,4- dihydroquinazolin-5-yl}-5- hydroxypyridine-2-carboxamide | US20230278981, Example 41 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15Cl2FN4O3 |
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| Mol. Mass. | 473.284 |
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| SMILES | C[C@@H](c1cccc(F)c1)n1cnc2cccc(NC(=O)c3cc(Cl)c(O)c(Cl)n3)c2c1=O |r| |
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| Structure | 
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