| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Ligand | BDBM21447 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization Competition Assay |
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| Ki | <40.0±n/a nM |
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| Citation |  Fletcher, S; Drennen, B Carboxylic acid, acyl sulfonamide and acyl sulfamide-derivatized bicyclic aza-heteroaromatics as selective Mcl-1 inhibitors and as dual Mcl-1/Bcl-2 inhibitors US Patent US11760752 Publication Date 9/19/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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| Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
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| Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
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| Mol. Mass.: | 26053.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_510901 |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM21447 |
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| n/a |
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| Name | BDBM21447 |
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| Synonyms: | 4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]benzamide | ABT-737 | CHEMBL376408 | N-Benylpiperazine derivative, 2 | US11760752, Compound ABT-737 | US9125913, ABT-737 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H45ClN6O5S2 |
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| Mol. Mass. | 813.427 |
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| SMILES | CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCN(Cc2ccccc2-c2ccc(Cl)cc2)CC1 |r| |
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| Structure | 
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