| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM619941 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kallikrein Inhibition Assay Utilizing a Quenched AMC Peptide Substrate |
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| IC50 | 1.000±n/a nM |
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| Citation |  XU, G; GAUL, MD; THIEU, TV; ZHANG, J; WALL, M; GAO, LH; ZHU, B; LU, T; GUO, B; LIU, Z; NARGUND, R; MACIELAG, MJ 3-(1H-IMIDAZOL-2-YL)-2,3,8,8A-TETRAHYDROINDOLIZIN-5(1H)-ONE DERIVATIVES USEFUL AS FACTOR XIA INHIBITORS US Patent US20230295157 Publication Date 9/21/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM619941 |
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| n/a |
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| Name | BDBM619941 |
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| Synonyms: | US20230295157, Example 265 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22ClFN10O |
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| Mol. Mass. | 544.971 |
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| SMILES | CNc1n[nH]c2cc(ccc12)-c1cnc([nH]1)[C@@H]1CC[C@H]2CC(=CC(=O)N12)c1c(F)c(Cl)ccc1-n1cnnn1 |r,c:24| |
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| Structure | 
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