Ki Summary

Reaction Details

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Target

Galectin-1

Ligand

BDBM620360

Substrate/Competitor

n/a

Meas. Tech.

Evaluation of Compound Inhibitory Activity (IC50)

IC50

320±n/a nM

Citation

BOLLLI, M; GATFIELD, J; GRISOSTOMI, C; REMEN, L; SAGER, C; ZUMBRUNN, C SPIRO DERIVATIVES OF ALPHA-D-GALACTOPYRANOSIDES US Patent US20230295182 Publication Date 9/21/2023

More Info.:

Get all data from this article, Assay Method

Galectin-1

Name:

Galectin-1

Synonyms:

Type:

beta galactoside-binding protein

Mol. Mass.:

14713.53

Organism:

Homo sapiens (Human)

Description:

P09382

Residue:

135

Sequence:

MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIV
CNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINY
MAADGDFKIKCVAFD

BDBM620360

n/a

Name

BDBM620360

Synonyms:

US20230295182, Example 2.10 | ethyl ((5r,8R)-3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3-methoxy- 4-(4-(2,3,4-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2- yl)methyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-yl)carbamate

Type

Small organic molecule

Emp. Form.

C27H34F3N5O7

Mol. Mass.

597.5834

SMILES

CCOC(=O)N[C@H]1CC[C@@]2(CC(C[C@H]3O[C@H](CO)[C@H](O)[C@@H]([C@H]3OC)n3cc(nn3)-c3ccc(F)c(F)c3F)=NO2)CC1 |wU:9.42,21.22,13.12,wD:20.24,15.15,18.18,6.5,c:40,(9.26,-1.95,;7.93,-2.72,;6.6,-1.95,;5.26,-2.72,;5.26,-4.26,;3.93,-1.95,;2.59,-2.72,;1.26,-1.95,;-.07,-2.72,;-.07,-4.26,;-1.48,-3.64,;-2.51,-4.78,;-4.04,-4.62,;-4.67,-3.21,;-6.2,-3.05,;-6.83,-1.65,;-8.36,-1.48,;-9.26,-2.73,;-5.92,-.4,;-6.55,1.01,;-4.39,-.56,;-3.76,-1.97,;-2.23,-2.13,;-1.33,-.88,;-3.48,.69,;-1.94,.69,;-1.47,2.15,;-2.71,3.06,;-3.96,2.15,;-0,2.63,;1.14,1.6,;2.61,2.07,;2.93,3.58,;4.39,4.05,;1.78,4.61,;2.1,6.11,;.32,4.13,;-.83,5.16,;-1.74,-6.11,;-.23,-5.79,;1.26,-5.03,;2.59,-4.26,)|

Structure