| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Ligand | BDBM176800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | MKNK1 Kinase High ATP Assay |
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| pH | 7.5±n/a |
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| IC50 | 445±n/a nM |
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| Comments | extracted |
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| Citation |  Klar, U; Wortmann, L; Graham, K; Puehler, F; Sülzle, D; Kettschau, G; Lienau, P Substituted thiazolopyrimidines US Patent US9675612 Publication Date 6/13/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Name: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] |
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| Synonyms: | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) 344D] | Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase signal-integrating kinase 1 (MNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1) (T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)(T344D) | MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D] | MAP kinase-interacting serine/threonine-protein kinase 1 (T344D) | MKNK1 | MKNK1 (aa 1-424) T344D | MKNK1_HUMAN | MNK1 | MNK1a |
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| Type: | Protein |
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| Mol. Mass.: | 47416.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BUB5-2 with T344D |
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| Residue: | 424 |
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| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCES
PEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKR
CDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWA
HISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPDPQVLQRNSSTMDLTLF
AAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSP
PTAL
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| BDBM176800 |
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| n/a |
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| Name | BDBM176800 |
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| Synonyms: | US9675612, 37 N-[2-(Dimethylamino)-2-oxoethyl]-N-methyl-7-[(2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino][1,3]thiazolo[5,4-d]pyrimidine-2-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N7O3S2 |
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| Mol. Mass. | 443.503 |
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| SMILES | CN(C)C(=O)CN(C)C(=O)c1nc2c(Nc3ccc4[nH]c(=O)sc4c3)ncnc2s1 |
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| Structure | 
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