| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM212562 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Activity Against Human Renin |
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| IC50 | 12.0±n/a nM |
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| Citation |  Iijima, T; Sugama, H; Kawaguchi, T; Shen, J; Xia, G; Xie, J; Hirai, M Nitrogen-containing saturated heterocyclic compound US Patent US10155731 Publication Date 12/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM212562 |
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| n/a |
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| Name | BDBM212562 |
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| Synonyms: | US10155731, Example 138 | US9278944, 138 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29ClN4O3 |
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| Mol. Mass. | 420.933 |
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| SMILES | COCCCn1cc(Cl)c2cnc(cc12)[C@H](C)N(C1CC1)C(=O)[C@H]1CNCCO1 |r| |
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| Structure | 
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