| Reaction Details |
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 | Report a problem with these data |
| Target | Activin receptor type-1 |
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| Ligand | BDBM621068 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Enzymatic Activity Inhibition Test (TGFbetaR1) |
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| IC50 | 2.36±0.68 nM |
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| Citation |  TIAN, Q; ZHANG, Y; JIANG, X; LIU, C; KANG, B; LIU, R; SONG, H; XUE, T; WANG, J PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF US Patent US20230303562 Publication Date 9/28/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Activin receptor type-1 |
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| Name: | Activin receptor type-1 |
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| Synonyms: | 2.7.11.30 | ACTR-I | ACVR1 | ACVR1_HUMAN | ACVRLK2 | ALK-2 | ALK2/ACVR1 | Activin receptor type I | Activin receptor-like kinase 2 | Activin receptor-like kinase 2 (ALK-2) | Activin receptor-like kinase 2 (ALK2/ACVR1) | Q04771 | SKR1 | Serine/threonine-protein kinase receptor R1 | TGF-B superfamily receptor type I | TSR-I |
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| Type: | n/a |
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| Mol. Mass.: | 57158.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 509 |
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| Sequence: | MVDGVMILPVLIMIALPSPSMEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSIN
DGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF
HLEVGLIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTL
ADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSR
DEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTL
DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVM
HSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVS
NGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
NPSARLTALRIKKTLTKIDNSLDKLKTDC
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| BDBM621068 |
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| n/a |
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| Name | BDBM621068 |
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| Synonyms: | US20230303562, Example 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N6 |
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| Mol. Mass. | 276.296 |
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| SMILES | Cc1cccc(n1)-n1nccc1-c1cnn2ccnc2c1 |
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| Structure | 
|
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