| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
|---|
| Ligand | BDBM622117 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | hFAP Inhibition Assay |
|---|
| IC50 | 0.051±n/a nM |
|---|
| Citation |  BRÅNALT, J; HOLM, B; JOHANSSON, M; KARLSSON, O; KNERR, DL; NORDQVIST, A; SHEPPARD, RJ; SWANSON, M; TOMBERG, A N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES US Patent US20230312550 Publication Date 10/5/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl endopeptidase FAP |
|---|
| Name: | Prolyl endopeptidase FAP |
|---|
| Synonyms: | 170 kDa melanoma membrane-bound gelatinase | FAP | Fibroblast Activation Protein (FAP) | Fibroblast activation protein alpha | Integral membrane serine protease | SEPR_HUMAN | Seprase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 87712.48 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q12884 |
|---|
| Residue: | 760 |
|---|
| Sequence: | MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPN
WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYG
DEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVT
DERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYD
AISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPG
RRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGR
TDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQ
ITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVY
TERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD
|
|
|
|---|
| BDBM622117 |
|---|
| n/a |
|---|
| Name | BDBM622117 |
|---|
| Synonyms: | US20230312550, Example 77 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N5O3S |
|---|
| Mol. Mass. | 423.488 |
|---|
| SMILES | O=C(CNC(=O)c1ccnc2ccc(cc12)N1CC2CC(C1)O2)N1CSC[C@H]1C#N |r| |
|---|
| Structure | 
|
|---|
Search and Browse
