| Reaction Details |
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 | Report a problem with these data |
| Target | Presequence protease, mitochondrial |
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| Ligand | BDBM622051 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | hPrep Inhibition Assay |
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| IC50 | 140±n/a nM |
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| Citation |  BRÅNALT, J; HOLM, B; JOHANSSON, M; KARLSSON, O; KNERR, DL; NORDQVIST, A; SHEPPARD, RJ; SWANSON, M; TOMBERG, A N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES US Patent US20230312550 Publication Date 10/5/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Presequence protease, mitochondrial |
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| Name: | Presequence protease, mitochondrial |
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| Synonyms: | KIAA1104 | MP1 | Metalloprotease 1 | PITRM1 | PREP | PREP_HUMAN | Pitrilysin metalloproteinase 1 | hMP1 | hPreP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117419.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108043 |
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| Residue: | 1037 |
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| Sequence: | MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPEL
FLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCR
DPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQE
GWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPL
CIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQ
TPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSP
FYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGF
EDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQE
NPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEK
GLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRA
FSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMD
TYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHL
YASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRC
SVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIR
KLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIR
EKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVF
STVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAI
LGPENPKIAKDPSWIIQ
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| BDBM622051 |
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| n/a |
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| Name | BDBM622051 |
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| Synonyms: | US20230312550, Example 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N5O3S |
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| Mol. Mass. | 409.462 |
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| SMILES | O=C(CNC(=O)c1ccnc2ccc(cc12)N1CCCC1=O)N1CSC[C@H]1C#N |r| |
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| Structure | 
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