Reaction Details |
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Target | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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Ligand | BDBM50198892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | holoenzyme assay |
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IC50 | 1200±130 nM |
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Citation | Horne, D; Lincoln, C Ribonucleotide reductase inhibitors and methods of use US Patent US10155732 Publication Date 12/18/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
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Name: | Ribonucleoside-diphosphate reductase large subunit/subunit M2 |
Synonyms: | RRM1/RRM2 holoenzyme | Ribonucleoside-diphosphate reductase M1/M2 chain |
Type: | Enzyme |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Ribonucleoside-diphosphate reductase large subunit |
Synonyms: | RIR1_HUMAN | RR1 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain | Ribonucleoside-diphosphate reductase subunit M1 | Ribonucleotide reductase large subunit |
Type: | PROTEIN |
Mol. Mass.: | 90074.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_90946 |
Residue: | 792 |
Sequence: | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLA
AETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKST
LDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHK
EDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCAL
ISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY
LEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLD
EVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNL
GTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKI
IDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGAL
EASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIA
PMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQII
ACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKL
TSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNTAAMVCS
LENRDECLMCGS
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Component 2 |
Name: | Ribonucleoside-diphosphate reductase subunit M2 |
Synonyms: | RIR2_HUMAN | RR2 | RRM2 | Ribonucleoside-diphosphate reductase M2 chain | Ribonucleotide reductase small chain | Ribonucleotide reductase small subunit |
Type: | PROTEIN |
Mol. Mass.: | 44868.59 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_195255 |
Residue: | 389 |
Sequence: | MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT
KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK
PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI
DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF
ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE
QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN
FFEKRVGEYQRMGVMSSPTENSFTLDADF
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BDBM50198892 |
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n/a |
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Name | BDBM50198892 |
Synonyms: | 3-AP | 3-aminopyridine-2-carboxaldehyde thiosemicarbazone | Triapine | US10155732, Compound 3-AP |
Type | Small organic molecule |
Emp. Form. | C7H9N5S |
Mol. Mass. | 195.245 |
SMILES | NC(=S)N\N=C\c1ncccc1N |
Structure |
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