| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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| Ligand | BDBM622516 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biological Assay |
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| IC50 | 67.0±n/a nM |
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| Citation |  Yu, C; Sun, Z; Liu, B; Zhang, C 1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS US Patent US20230312583 Publication Date 10/5/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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| Name: | Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 |
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| Synonyms: | CDK6/Cyclin D1 |
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| Type: | Enzyme |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| Component 2 |
| Name: | G1/S-specific cyclin-D1 |
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| Synonyms: | CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33418.84 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 295 |
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| Sequence: | MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIV
ATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLT
AEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRK
HAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCD
PDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
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| BDBM622516 |
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| n/a |
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| Name | BDBM622516 |
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| Synonyms: | US20230312583, Compound I-12 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N8O |
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| Mol. Mass. | 444.5321 |
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| SMILES | COc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CC2CCC1CN2 |
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| Structure | 
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