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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | ||
| Ligand | BDBM624755 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | LRRK2 Wild-Type and G2019S Kinase Activity Assay | ||
| IC50 | 5.10±n/a nM | ||
| Citation |  Jensen, T; Jessing, M; Yu, W; Diaz, DR; Nielsen, J; Jones, CR; Andersen, T; Jacobsen, MF LRRK2 inhibitors US Patent US11780851 Publication Date 10/10/2023 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | |||
| Name: | Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] | ||
| Synonyms: | LRRK2 | LRRK2 G2019S | LRRK2_HUMAN | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) (G2019S) | Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)(G2019S) | Leucine-rich repeat serine/threonine-protein kinase 2 G2019S | PARK8 | ||
| Type: | n/a | ||
| Mol. Mass.: | 286143.23 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q5S007(G2019S) | ||
| Residue: | 2527 | ||
| Sequence: |
| ||
| BDBM624755 | |||
| n/a | |||
| Name | BDBM624755 | ||
| Synonyms: | US11780851, Example 25 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H21ClFN7O | ||
| Mol. Mass. | 405.857 | ||
| SMILES | Cc1c2Nc3ncc4c(Cl)nn(CCCOc2nn1[C@H]1CC[C@H](F)CC1)c4n3 |r,wU:22.24,wD:19.20,(-6.63,6.73,;-5.38,5.83,;-3.89,6.39,;-3.44,7.87,;.85,9.05,;2.09,9.96,;3.5,9.33,;3.66,7.8,;4.91,6.89,;6.37,7.37,;4.43,5.43,;2.89,5.43,;2.12,4.09,;.79,3.32,;-.7,3.72,;-1.47,5.06,;-3.01,5.06,;-3.92,3.81,;-5.38,4.29,;-6.63,3.38,;-8.03,4.01,;-9.28,3.1,;-9.12,1.57,;-10.37,.67,;-7.71,.94,;-6.47,1.85,;2.41,6.89,;1.01,7.52,)| | ||
| Structure | 
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