| Reaction Details |
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 | Report a problem with these data |
| Target | csnk1d |
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| Ligand | BDBM625275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | CSNK1D Assay |
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| IC50 | 11.0±n/a nM |
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| Citation |  Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Rauh, U; Bömer, U; Hillig, R; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; McKinney, D ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF US Patent US20230322767 Publication Date 10/12/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| csnk1d |
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| Name: | Casein kinase I isoform delta |
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| Synonyms: | CKI-delta | CKId | CSNK1D | Casein kinase 1 delta (CK1δ) | Casein kinase I delta | Casein kinase I isoform alpha/delta | Casein kinase I isoform delta (CK1D) | HCKID | KC1D_HUMAN | casein kinases 1 delta (CK1 delta) |
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| Type: | Enzyme |
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| Mol. Mass.: | 47356.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P48730 |
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| Residue: | 415 |
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| Sequence: | MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQ
GGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRA
ADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPV
SGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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| BDBM625275 |
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| n/a |
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| Name | BDBM625275 |
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| Synonyms: | 2-(4-fluorophenyl)-N-[4-(5-methyl-4-oxo-3-phenyl-4,5-dihydro-1H-pyrrolo[3,2-c]pyridin-2-yl)pyridin-2-yl]propanamide (Racemate) | US20230322767, Example 103 | US20230322767, Example 104 | US20230322767, Example 105 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H23FN4O2 |
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| Mol. Mass. | 466.5062 |
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| SMILES | CC(C(=O)Nc1cc(ccn1)-c1[nH]c2ccn(C)c(=O)c2c1-c1ccccc1)c1ccc(F)cc1 |
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| Structure | 
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