| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional enhancer factor TEF-3 |
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| Ligand | BDBM626318 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | 20.0±n/a nM |
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| Citation |  Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional enhancer factor TEF-3 |
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| Name: | Transcriptional enhancer factor TEF-3 |
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| Synonyms: | RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48333.01 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118073 |
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| Residue: | 434 |
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| Sequence: | MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPP
CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQ
AAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPF
SQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPD
TYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWA
DLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYR
IHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSAS
EHGAQHHIYRLVKE
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|
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| BDBM626318 |
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| n/a |
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| Name | BDBM626318 |
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| Synonyms: | 2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid | US11787775, Compound 3 | US11787775, Compound 40 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22N2O3 |
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| Mol. Mass. | 362.4217 |
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| SMILES | CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 |
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| Structure | 
|
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