| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional enhancer factor TEF-1 |
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| Ligand | BDBM626364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | 310±n/a nM |
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| Citation |  Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional enhancer factor TEF-1 |
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| Name: | Transcriptional enhancer factor TEF-1 |
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| Synonyms: | NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47954.57 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_109666 |
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| Residue: | 426 |
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| Sequence: | MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIIL
SDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQ
HMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAY
PIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFV
HIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQD
DAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCE
YMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHI
YRLVKD
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|
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| BDBM626364 |
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| n/a |
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| Name | BDBM626364 |
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| Synonyms: | 2-[[[4-cyano-7-(5-isopropylthiazol- 2-yl)-2,3-dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid | US11787775, Compound 49 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N3O3S |
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| Mol. Mass. | 369.437 |
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| SMILES | CC(C)c1cnc(s1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2CCOc12 |
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| Structure | 
|
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