| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transcriptional enhancer factor TEF-1/Isoform 5 of Transcriptional coactivator [50-100] |
|---|
| Ligand | BDBM626326 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | HTRF Assay |
|---|
| EC50 | 320±n/a nM |
|---|
| Citation |  Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transcriptional enhancer factor TEF-1/Isoform 5 of Transcriptional coactivator [50-100] |
|---|
| Name: | Transcriptional enhancer factor TEF-1/Isoform 5 of Transcriptional coactivator [50-100] |
|---|
| Synonyms: | TEAD1 YAP50-100 combined |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Transcriptional enhancer factor TEF-1 |
|---|
| Synonyms: | NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47954.57 |
|---|
| Organism: | Homo sapiens |
|---|
| Description: | ChEMBL_109666 |
|---|
| Residue: | 426 |
|---|
| Sequence: | MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIIL
SDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQ
HMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAY
PIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFV
HIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQD
DAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCE
YMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHI
YRLVKD
|
|
|
|---|
| Component 2 |
| Name: | Isoform 5 of Transcriptional coactivator [50-100] |
|---|
| Synonyms: | Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 5701.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P46937-5[50-100] |
|---|
| Residue: | 51 |
|---|
| Sequence: | AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
|
|
|
|---|
| BDBM626326 |
|---|
| n/a |
|---|
| Name | BDBM626326 |
|---|
| Synonyms: | 7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-butyl)amino]-2,3- dihydrobenzofuran-4-carbonitrile | US11787775, Compound 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H24N2O2 |
|---|
| Mol. Mass. | 360.4489 |
|---|
| SMILES | CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(C)=O)c(C#N)c2CCOc12 |
|---|
| Structure | 
|
|---|
Search and Browse
