| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional enhancer factor TEF-4/Isoform 5 of Transcriptional coactivator [50-100] |
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| Ligand | BDBM626326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| EC50 | 130±n/a nM |
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| Citation |  Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional enhancer factor TEF-4/Isoform 5 of Transcriptional coactivator [50-100] |
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| Name: | Transcriptional enhancer factor TEF-4/Isoform 5 of Transcriptional coactivator [50-100] |
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| Synonyms: | TEAD2 YAP50-100 combined |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Transcriptional enhancer factor TEF-4 |
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| Synonyms: | TEA domain family member 2 | TEAD-2 | TEAD2 | TEAD2_HUMAN | TEF4 | Transcriptional enhancer factor TEF-4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49241.42 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119051 |
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| Residue: | 447 |
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| Sequence: | MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIY
PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLK
DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPF
SQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPP
DAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLV
KFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVET
ERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQEL
LLCTAYVFEVSTSERGAQHHIYRLVRD
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| Component 2 |
| Name: | Isoform 5 of Transcriptional coactivator [50-100] |
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| Synonyms: | Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 5701.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46937-5[50-100] |
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| Residue: | 51 |
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| Sequence: | AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
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| BDBM626326 |
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| n/a |
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| Name | BDBM626326 |
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| Synonyms: | 7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-butyl)amino]-2,3- dihydrobenzofuran-4-carbonitrile | US11787775, Compound 11 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24N2O2 |
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| Mol. Mass. | 360.4489 |
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| SMILES | CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(C)=O)c(C#N)c2CCOc12 |
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| Structure | 
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