Reaction Details |
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Target | Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100] |
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Ligand | BDBM626354 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HTRF Assay |
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IC50 | 140±n/a nM |
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Citation | Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100] |
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Name: | Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100] |
Synonyms: | TEAD4 YAP50-100 combined |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Transcriptional enhancer factor TEF-3 |
Synonyms: | RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3 |
Type: | PROTEIN |
Mol. Mass.: | 48333.01 |
Organism: | Homo sapiens |
Description: | ChEMBL_118073 |
Residue: | 434 |
Sequence: | MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPP
CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQ
AAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPF
SQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPD
TYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWA
DLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYR
IHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSAS
EHGAQHHIYRLVKE
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Component 2 |
Name: | Isoform 5 of Transcriptional coactivator [50-100] |
Synonyms: | Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 5701.47 |
Organism: | Homo sapiens (Human) |
Description: | P46937-5[50-100] |
Residue: | 51 |
Sequence: | AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
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BDBM626354 |
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n/a |
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Name | BDBM626354 |
Synonyms: | 2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluoromethoxy)phenyl]-3H- benzofuran-5-yl]amino]methyl]prop- 2-enehydroxamic acid | US11787775, Compound 37 | US11787775, Compound 39 |
Type | Small organic molecule |
Emp. Form. | C20H16F3N3O4 |
Mol. Mass. | 419.3539 |
SMILES | ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1 |
Structure |
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