| Reaction Details |
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 | Report a problem with these data |
| Target | Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100] |
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| Ligand | BDBM626361 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HTRF Assay |
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| IC50 | 120±n/a nM |
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| Citation |  Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent US11787775 Publication Date 10/17/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100] |
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| Name: | Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100] |
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| Synonyms: | TEAD4 YAP50-100 combined |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Transcriptional enhancer factor TEF-3 |
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| Synonyms: | RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48333.01 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118073 |
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| Residue: | 434 |
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| Sequence: | MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPP
CGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQ
AAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPF
SQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPD
TYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWA
DLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYR
IHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSAS
EHGAQHHIYRLVKE
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| Component 2 |
| Name: | Isoform 5 of Transcriptional coactivator [50-100] |
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| Synonyms: | Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 5701.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46937-5[50-100] |
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| Residue: | 51 |
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| Sequence: | AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
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| BDBM626361 |
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| n/a |
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| Name | BDBM626361 |
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| Synonyms: | 2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid | US11787775, Compound 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15F5N2O3S |
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| Mol. Mass. | 446.391 |
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| SMILES | OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)S(F)(F)(F)(F)F |
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| Structure | 
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