| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-type tyrosine-protein kinase FLT3 [564-960] |
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| Ligand | BDBM311114 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FLT3 Kinase Test |
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| IC50 | 2230±n/a nM |
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| Citation |  Hoffmann, M; Dahmann, G; Gnamm, C; Fandrick, DR; Scott, J; McCarthy, C Pyrazolyl-substituted heteroaryls and their use as medicaments US Patent US10155751 Publication Date 12/18/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-type tyrosine-protein kinase FLT3 [564-960] |
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| Name: | Receptor-type tyrosine-protein kinase FLT3 [564-960] |
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| Synonyms: | CD135 | FLK2 | FLT3 | FLT3 (aa 564-960) | FLT3_HUMAN | STK1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 45855.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36888[564-960] |
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| Residue: | 397 |
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| Sequence: | HKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGK
VMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTL
SGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREV
QIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLE
FKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEG
IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQ
SCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
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| BDBM311114 |
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| n/a |
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| Name | BDBM311114 |
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| Synonyms: | US10155751, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24FN5O2 |
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| Mol. Mass. | 397.446 |
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| SMILES | C[C@@H](Oc1cc(cc2nn(C)c(F)c12)-c1cnn(c1)C1CCC1)[C@H]1CNC(=O)C1 |r| |
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| Structure | 
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