| Reaction Details |
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 | Report a problem with these data |
| Target | Protein O-GlcNAcase |
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| Ligand | BDBM628194 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Human O-GlcNAcase Enzyme Inhibition Assay |
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| IC50 | <50±n/a nM |
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| Citation |  Quattropani, A; Kulkarni, SS; Giri, AG; Wishart, G; Rakesh, P Tetrahydro-benzoazepine glycosidase inhibitors US Patent US11795165 Publication Date 10/24/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein O-GlcNAcase |
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| Name: | Protein O-GlcNAcase |
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| Synonyms: | 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | Beta-N-acetylhexosaminidase | Beta-hexosaminidase (O-GlcNAcase) | Bifunctional protein NCOAT | HEXC | KIAA0679 | MEA5 | MGEA5 | N-acetyl-beta-D-glucosaminidase (O-GlcNAcase) | O-glycoprotein 2-acetamido-2-deoxy-β-D-glucopyranosidase (O-GlcNAcase) | OGA | OGA_HUMAN | Protein O-GlcNAcase |
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| Type: | Enzyme |
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| Mol. Mass.: | 102874.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60502 |
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| Residue: | 916 |
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| Sequence: | MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
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| BDBM628194 |
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| n/a |
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| Name | BDBM628194 |
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| Synonyms: | US11795165, Compound 113 | US11795165, Compound 114 | US11795165, Compound 115 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3OS2 |
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| Mol. Mass. | 385.546 |
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| SMILES | CC(N1CCc2ccc(cc2CC1)S(C)(=N)=O)c1ccc2scnc2c1 |w:1.0,8.14,13.15| |
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| Structure | 
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