| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysosomal alpha-glucosidase |
|---|
| Ligand | BDBM50583379 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition of rhGAA Determined by Measuring the Residual Activity in the Presence of an Inhibitor in Vitro |
|---|
| IC50 | 390±n/a nM |
|---|
| Citation |  PY, S; KANAZAWA, A; VIEIRA DA CRUZ, A; TANGARA, S NOVEL PHARMACOLOGICAL CHAPERONE COMPOUNDS OF HUMAN ACID ALPHA-GLUCOSIDASE AND THE THERAPEUTIC USE THEREOF US Patent US20230339856 Publication Date 10/26/2023 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysosomal alpha-glucosidase |
|---|
| Name: | Lysosomal alpha-glucosidase |
|---|
| Synonyms: | 70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | Alpha glucosidase | GAA | LYAG_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 105312.45 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1506060 |
|---|
| Residue: | 952 |
|---|
| Sequence: | MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLEETHPAHQQGA
SRPGPRDAQAHPGRPRAVPTQCDVPPNSRFDCAPDKAITQEQCEARGCCYIPAKQGLQGA
QMGQPWCFFPPSYPSYKLENLSSSEMGYTATLTRTTPTFFPKDILTLRLDVMMETENRLH
FTIKDPANRRYEVPLETPHVHSRAPSPLYSVEFSEEPFGVIVRRQLDGRVLLNTTVAPLF
FADQFLQLSTSLPSQYITGLAEHLSPLMLSTSWTRITLWNRDLAPTPGANLYGSHPFYLA
LEDGGSAHGVFLLNSNAMDVVLQPSPALSWRSTGGILDVYIFLGPEPKSVVQQYLDVVGY
PFMPPYWGLGFHLCRWGYSSTAITRQVVENMTRAHFPLDVQWNDLDYMDSRRDFTFNKDG
FRDFPAMVQELHQGGRRYMMIVDPAISSSGPAGSYRPYDEGLRRGVFITNETGQPLIGKV
WPGSTAFPDFTNPTALAWWEDMVAEFHDQVPFDGMWIDMNEPSNFIRGSEDGCPNNELEN
PPYVPGVVGGTLQAATICASSHQFLSTHYNLHNLYGLTEAIASHRALVKARGTRPFVISR
STFAGHGRYAGHWTGDVWSSWEQLASSVPEILQFNLLGVPLVGADVCGFLGNTSEELCVR
WTQLGAFYPFMRNHNSLLSLPQEPYSFSEPAQQAMRKALTLRYALLPHLYTLFHQAHVAG
ETVARPLFLEFPKDSSTWTVDHQLLWGEALLITPVLQAGKAEVTGYFPLGTWYDLQTVPV
EALGSLPPPPAAPREPAIHSEGQWVTLPAPLDTINVHLRAGYIIPLQGPGLTTTESRQQP
MALAVALTKGGEARGELFWDDGESLEVLERGAYTQVIFLARNNTIVNELVRVTSEGAGLQ
LQKVTVLGVATAPQQVLSNGVPVSNFTYSPDTKVLDICVSLLMGEQFLVSWC
|
|
|
|---|
| BDBM50583379 |
|---|
| n/a |
|---|
| Name | BDBM50583379 |
|---|
| Synonyms: | CHEMBL5028138 | US20230339856, Compound (IIb) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H19NO4 |
|---|
| Mol. Mass. | 205.2515 |
|---|
| SMILES | CCC[C@]1(CO)NC[C@H](O)[C@@H](O)[C@@H]1O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
