| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 11 |
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| Ligand | BDBM628498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SHP2 Allosteric Inhibitory Enzyme Activity Assay |
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| IC50 | 1.10±n/a nM |
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| Citation |  WU, H; WU, W; LI, L; ZHANG, Z; WANG, F; YUAN, D; WU, Y; CHEN, Q; HAN, H; GUO, J; LAN, H; DING, L; WANG, J SHP2 INHIBITOR AND COMPOSITION AND APPLICATION THEREOF US Patent US20230339882 Publication Date 10/26/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 11 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 11 |
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| Synonyms: | 3.1.3.48 | PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 1D | Protein-tyrosine phosphatase 2C | SH-PTP2 | SH-PTP3 | SHP-2 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 68443.59 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q06124 |
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| Residue: | 593 |
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| Sequence: | MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
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| BDBM628498 |
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| n/a |
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| Name | BDBM628498 |
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| Synonyms: | US20230339882, Example A03 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31N5O3 |
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| Mol. Mass. | 485.5774 |
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| SMILES | COc1cc(N)cc(OCC#Cc2cnc(N3CCC4(Cc5ccccc5[C@H]4N)CC3)c(CO)n2)c1 |
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| Structure | 
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