| Reaction Details |
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 | Report a problem with these data |
| Target | Sterol regulatory element-binding protein 2 |
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| Ligand | BDBM630060 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay-SREBP-2 |
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| IC50 | 125±n/a nM |
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| Citation |  Feula, A; Salituro, FG; Stites, RE STEROIDAL COMPOSITIONS AND METHODS OF TREATING LIPOGENIC CANCERS US Patent US20230340011 Publication Date 10/26/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sterol regulatory element-binding protein 2 |
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| Name: | Sterol regulatory element-binding protein 2 |
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| Synonyms: | BHLHD2 | SRBP2_HUMAN | SREBF2 | SREBP2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123713.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_765690 |
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| Residue: | 1141 |
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| Sequence: | MDDSGELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFPDLFSEQLCSSFPGSGGS
GSSSGSSGSSSSSSNGRGSSSGAVDPSVQRSFTQVTLPSFSPSAASPQAPTLQVKVSPTS
VPTTPRATPILQPRPQPQPQPQTQLQQQTVMITPTFSTTPQTRIIQQPLIYQNAATSFQV
LQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVAAPQVQQVP
VLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTTPIQTAALQVPTLVGSSGTILT
TMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGT
DAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDNEVDLK
IEDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRS
RILLCVLTFLCLSFNPLTSLLQWGGAHDSDQHPHSGSGRSVLSFESGSGGWFDWMMPTLL
LWLVNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLARGDFAAAAGNLQTC
LAVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQCRRATPATEAGFEDEAK
TSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTA
AMGLKTRCGGKLGFLASYFLSRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSVKSA
AKESLYCAQRNPADPIAQVHQAFCKNLLERAIESLVKPQAKKKAGDQEEESCEFSSALEY
LKLLHSFVDSVGVMSPPLSRSSVLKSALGPDIICRWWTSAITVAISWLQGDDAAVRSHFT
KVERIPKALEVTESPLVKAIFHACRAMHASLPGKADGQQSSFCHCERASGHLWSSLNVSG
ATSDPALNHVVQLLTCDLLLSLRTALWQKQASASQAVGETYHASGAELAGFQRDLGSLRR
LAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQSTKHGEVDAWPGQRER
ATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCNDCQQMIVKLGGGTAIAA
S
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| BDBM630060 |
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| n/a |
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| Name | BDBM630060 |
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| Synonyms: | US20230340011, Example 359. |
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| Type | Small organic molecule |
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| Emp. Form. | C28H47N3O4S |
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| Mol. Mass. | 521.755 |
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| SMILES | C[C@H](CCC(=O)N1CCN(CC1)S(N)(=O)=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C |r,t:23| |
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| Structure | 
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