Reaction Details |
| Report a problem with these data |
Target | Leucine--tRNA ligase |
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Ligand | BDBM630397 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Isothermal Titration Calorimetry (ITC) |
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Kd | 4.47±0.04 nM |
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Citation | Finn, PW; Charlton, M; Edmund, G; Jirgensons, A; Loza, E 2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase US Patent US11802110 Publication Date 10/31/2023 |
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More Info.: | Get all data from this article, Assay Method |
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Leucine--tRNA ligase |
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Name: | Leucine--tRNA ligase |
Synonyms: | 6.1.1.4 | LeuRS | Leucine--tRNA ligase | Leucyl-tRNA synthetase | SYL_ECOLI | leuS |
Type: | PROTEIN |
Mol. Mass.: | 97211.51 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_117811 |
Residue: | 860 |
Sequence: | MQEQYRPEEIESKVQLHWDEKRTFEVTEDESKEKYYCLSMLPYPSGRLHMGHVRNYTIGD
VIARYQRMLGKNVLQPIGWDAFGLPAEGAAVKNNTAPAPWTYDNIAYMKNQLKMLGFGYD
WSRELATCTPEYYRWEQKFFTELYKKGLVYKKTSAVNWCPNDQTVLANEQVIDGCCWRCD
TKVERKEIPQWFIKITAYADELLNDLDKLDHWPDTVKTMQRNWIGRSEGVEITFNVNDYD
NTLTVYTTRPDTFMGCTYLAVAAGHPLAQKAAENNPELAAFIDECRNTKVAEAEMATMEK
KGVDTGFKAVHPLTGEEIPVWAANFVLMEYGTGAVMAVPGHDQRDYEFASKYGLNIKPVI
LAADGSEPDLSQQALTEKGVLFNSGEFNGLDHEAAFNAIADKLTAMGVGERKVNYRLRDW
GVSRQRYWGAPIPMVTLEDGTVMPTPDDQLPVILPEDVVMDGITSPIKADPEWAKTTVNG
MPALRETDTFDTFMESSWYYARYTCPQYKEGMLDSEAANYWLPVDIYIGGIEHAIMHLLY
FRFFHKLMRDAGMVNSDEPAKQLLCQGMVLADAFYYVGENGERNWVSPVDAIVERDEKGR
IVKAKDAAGHELVYTGMSKMSKSKNNGIDPQVMVERYGADTVRLFMMFASPADMTLEWQE
SGVEGANRFLKRVWKLVYEHTAKGDVAALNVDALTENQKALRRDVHKTIAKVTDDIGRRQ
TFNTAIAAIMELMNKLAKAPTDGEQDRALMQEALLAVVRMLNPFTPHICFTLWQELKGEG
DIDNAPWPVADEKAMVEDSTLVVVQVNGKVRAKITVPVDATEEQVRERAGQEHLVAKYLD
GVTVRKVIYVPGKLLNLVVG
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BDBM630397 |
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n/a |
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Name | BDBM630397 |
Synonyms: | US11802110, Compound 4.17 |
Type | Small organic molecule |
Emp. Form. | C18H22N2O2S |
Mol. Mass. | 330.444 |
SMILES | CC(C)CC(N)C(=O)NS(=O)c1cccc(c1)-c1ccccc1 |
Structure |
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