| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF18A |
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| Ligand | BDBM636927 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition of KIF18A Microtubule-Dependent ATPase Activity |
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| IC50 | 6.00±n/a nM |
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| Citation |  COGAN, DA COMPOUNDS FOR INHIBITING KIF18A US Patent US20230382889 Publication Date 11/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF18A |
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| Name: | Kinesin-like protein KIF18A |
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| Synonyms: | KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102320.22 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119153 |
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| Residue: | 898 |
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| Sequence: | MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTT
NQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKT
HTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVR
EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQD
KTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR
KNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLK
SNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIE
RFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKR
DHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHH
LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESD
FKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVK
IPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTV
TLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK
CKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNS
SLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
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| BDBM636927 |
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| n/a |
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| Name | BDBM636927 |
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| Synonyms: | N-(4-(4-(2-(4,4-difluoropiperidin-1- yl)thiazol-4-yl)-1H-1,2,3-triazol-1-yl)-3- (6-azaspiro[2.5]octan-6-yl)phenyl)-2- hydroxyethane-1-sulfonamide | US20230382889, Compound 69 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31F2N7O3S2 |
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| Mol. Mass. | 579.686 |
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| SMILES | OCCS(=O)(=O)Nc1ccc(c(c1)N1CCC2(CC2)CC1)-n1cc(nn1)-c1csc(n1)N1CCC(F)(F)CC1 |
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| Structure | 
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