| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF18A |
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| Ligand | BDBM636903 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Kinetic Assay |
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| Ki | 0.200±n/a nM |
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| Citation |  COGAN, DA COMPOUNDS FOR INHIBITING KIF18A US Patent US20230382889 Publication Date 11/30/2023 |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF18A |
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| Name: | Kinesin-like protein KIF18A |
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| Synonyms: | KI18A_HUMAN | KIF18A | Kinesin-like protein KIF18A | MS-KIF18A | Marrow stromal KIF18A |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102320.22 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_119153 |
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| Residue: | 898 |
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| Sequence: | MSVTEEDLCHHMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTT
NQNVIKKQNKDLKFVFDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKT
HTMLGSADEPGVMYLTMLHLYKCMDEIKEEKICSTAVSYLEVYNEQIRDLLVNSGPLAVR
EDTQKGVVVHGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQD
KTASINQNVRIAKMSLIDLAGSERASTSGAKGTRFVEGTNINRSLLALGNVINALADSKR
KNQHIPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLK
SNVLNVNNHITQYVKICNEQKAEILLLKEKLKAYEEQKAFTNENDQAKLMISNPQEKEIE
RFQEILNCLFQNREEIRQEYLKLEMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKR
DHRLAMLKTRRSYLEKRREEELKQFDENTNWLHRVEKEMGLLSQNGHIPKELKKDLHCHH
LHLQNKDLKAQIRHMMDLACLQEQQHRQTEAVLNALLPTLRKQYCTLKEAGLSNAAFESD
FKEIEHLVERKKVVVWADQTAEQPKQNDLPGISVLMTFPQLGPVQPIPCCSSSGGTNLVK
IPTEKRTRRKLMPSPLKGQHTLKSPPSQSVQLNDSLSKELQPIVYTPEDCRKAFQNPSTV
TLMKPSSFTTSFQAISSNINSDNCLKMLCEVAIPHNRRKECGQEDLDSTFTICEDIKSSK
CKLPEQESLPNDNKDILQRLDPSSFSTKHSMPVPSMVPSYMAMTTAAKRKRKLTSSTSNS
SLTADVNSGFAKRVRQDNSSEKHLQENKPTMEHKRNICKINPSMVRKFGRNISKGNLR
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| BDBM636903 |
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| n/a |
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| Name | BDBM636903 |
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| Synonyms: | N-(4-(4-(2-(4,4-difluoropiperidin-1-yl)-6- methylpyrimidin-4-yl)-1H-1,2,3-triazol-1- yl)-3-(6-azaspiro[2.5]octan-6-yl)phenyl)- 2-hydroxyethane-1-sulfonamide | US20230382889, Compound 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34F2N8O3S |
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| Mol. Mass. | 588.672 |
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| SMILES | Cc1cc(nc(n1)N1CCC(F)(F)CC1)-c1cn(nn1)-c1ccc(NS(=O)(=O)CCO)cc1N1CCC2(CC2)CC1 |
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| Structure | 
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